The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 14, 2017

Filed:

Jun. 17, 2014
Applicants:

Icahn School of Medicine AT Mount Sinai, New York, NY (US);

Yale University, New Haven, CT (US);

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Rockville, MD (US);

Inventors:

Dennis S. Charney, New York, NY (US);

Sanjay J. Mathew, New York, NY (US);

Husseini K. Manji, Rockville, MD (US);

Carlos A. Zarate, Rockville, MD (US);

John H. Krystal, New Haven, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/135 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 31/137 (2006.01); A61K 45/06 (2006.01); A61M 15/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/135 (2013.01); A61K 9/0019 (2013.01); A61K 9/0043 (2013.01); A61K 9/7023 (2013.01); A61K 31/137 (2013.01); A61K 45/06 (2013.01); A61M 15/08 (2013.01);
Abstract

Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).


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