The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Feb. 12, 2015
Applicant:
Celgene Corporation, Summit, NJ (US);
Inventors:
Anjan Thakurta, Basking Ridge, NJ (US);
Anita Gandhi, Bernardsville, NJ (US);
Michelle F. Waldman, Florham Park, NJ (US);
Rajesh Chopra, Summit, NJ (US);
Michael Amatangelo, Newtown, PA (US);
Chad Bjorklund, Summit, NJ (US);
Assignee:
CELGENE CORPORATION, Summit, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); G01N 33/68 (2006.01); G01N 33/574 (2006.01); A61K 31/454 (2006.01); A61K 31/517 (2006.01); C07K 14/47 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/454 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); C07K 14/47 (2013.01); G01N 33/57496 (2013.01); G01N 33/6872 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4703 (2013.01); G01N 2800/52 (2013.01);
Abstract
Provided herein are cereblon isoforms and methods of their use as biomarkers for treating a disease, disorder, or condition with a treatment compound, e.g., thalidomide, lenalidomide, pomalidomide, 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)-piperidine-2,6-dione, or (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione.