The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 07, 2017

Filed:

Feb. 26, 2016
Applicant:

Synthetic Biologics, Inc., Rockville, MD (US);

Inventors:

Pertti Koski, Helsinki, FI;

Ulla Airaksinen, Vantaa, FI;

Katja Valimaki, Vantaa, FI;

Assignee:

SYNTHETIC BIOLOGICS, INC., Rockville, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/50 (2006.01); A61K 31/43 (2006.01); A61K 31/545 (2006.01); C12N 9/86 (2006.01); A61K 45/06 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/86 (2013.01); A61K 31/43 (2013.01); A61K 31/545 (2013.01); A61K 38/50 (2013.01); A61K 45/06 (2013.01); A61K 38/00 (2013.01); C12Y 305/02006 (2013.01);
Abstract

The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and pharmaceutical compositions comprising the beta-lactamases. Also, the present invention relates to methods for modifying a beta-lactamase, producing the beta-lactamase and treating or preventing beta-lactam antibiotic induced adverse effects. Furthermore, the present invention relates to the beta-lactamase for use as a medicament and to the use of the beta-lactamase in the manufacture of a medicament for treating or preventing beta-lactam antibiotics induced adverse effects. Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.


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