The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Jan. 20, 2015
Applicant:
Ucb Pharma, S.a., Brussels, BE;
Inventors:
Mark Ellis, Slough, GB;
David Paul Humphreys, Slough, GB;
Assignee:
UCB PHARMA, S.A., Brussels, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/04 (2006.01); C07K 14/245 (2006.01); C12N 9/52 (2006.01); C12N 15/70 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0006 (2013.01); C07K 14/245 (2013.01); C12N 9/52 (2013.01); C12N 15/70 (2013.01); C12Y 101/01 (2013.01);
Abstract
The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.