The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Dec. 08, 2015
The Regents of the University of Michigan, Ann Arbor, MI (US);
Imra of America, Inc., Ann Arbor, MI (US);
Duxin Sun, Ann Arbor, MI (US);
Hongwei Chen, Ann Arbor, MI (US);
Wei Qian, Ann Arbor, MI (US);
Yong Che, Ann Arbor, MI (US);
Masayuki Ito, Cupertino, CA (US);
Hayley Paholak, Ann Arbor, MI (US);
Kanokwan Sansanaphongpricha, Ann Arbor, MI (US);
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
IMRA OF AMERICA, INC., Ann Arbor, MI (US);
Abstract
The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).