The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Apr. 01, 2011
Peter Kufer, Münich, DE;
Ralf Lutterbuese, Munich, DE;
Matthias Klinger, Munich, DE;
Petra Fluhr, Munich, DE;
Doris Rau, Munich, DE;
Susanne Hausmann, Munich, DE;
Carola Steiger, Munich, DE;
Tobias Raum, Munich, DE;
Patrick Hoffmann, Munich, DE;
Roman Kischel, Munich, DE;
Evelyne Schaller, Munich, DE;
Susanne Mangold, Munich, DE;
Peter Kufer, Münich, DE;
Ralf Lutterbuese, Munich, DE;
Matthias Klinger, Munich, DE;
Petra Fluhr, Munich, DE;
Doris Rau, Munich, DE;
Susanne Hausmann, Munich, DE;
Carola Steiger, Munich, DE;
Tobias Raum, Munich, DE;
Patrick Hoffmann, Munich, DE;
Roman Kischel, Munich, DE;
Evelyne Schaller, Munich, DE;
Susanne Mangold, Munich, DE;
AMGEN RESEARCH (MUNICH) GMBH, Munich, DE;
Abstract
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.