The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Sep. 03, 2014
Applicant:
Aptevo Biotherapeutics Llc, Seattle, WA (US);
Inventors:
William N. Drohan, Springfiled, VA (US);
Michael J. Griffith, San Juan Capistrano, CA (US);
Assignee:
APTEVO BIOTHERAPEUTICS LLC, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C07K 14/745 (2006.01); A61K 38/36 (2006.01); C12N 9/50 (2006.01);
U.S. Cl.
CPC ...
C07K 14/745 (2013.01); A61K 38/36 (2013.01); C12N 9/50 (2013.01); C12P 21/02 (2013.01);
Abstract
Methods for producing cell lines with high levels of biologically active recombinant vitamin K dependent proteins are described. The transfected cell lines do not include heterologous genes for processing enzymes and are not subject to selection pressure such as methotrexate resistance. Cell lines producing Factor VII/VIIa and Factor IX are described. These cell lines can be used for isolation of Factor VII/VIIa and/or Factor IX for treatment of Hemophilia.