The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 07, 2017

Filed:

Nov. 24, 2014
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Dansu LI, Warrington, PA (US);

Mark E. Layton, West Point, PA (US);

Anthony J. Roecker, West Point, PA (US);

Melissa Egbertson, Ambler, PA (US);

Kristen L. G. Jones, West Point, PA (US);

Xiu Wang, Shanghai, CN;

Xuanjia Peng, Shanghai, CN;

Inventors:

Mark E. Layton, West Point, PA (US);

Anthony J. Roecker, West Point, PA (US);

Melissa Egbertson, West Point, PA (US);

Kristen L. G. Jones, West Point, PA (US);

Dansu Li, Warrington, PA (US);

Xiu Wang, Shanghai, CN;

Xuanjia Peng, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/407 (2006.01); C07D 471/04 (2006.01); A61K 31/4353 (2006.01); C07D 491/20 (2006.01); C07D 487/10 (2006.01); C07D 277/52 (2006.01); C07D 213/76 (2006.01); C07D 239/42 (2006.01); C07D 237/20 (2006.01); C07D 285/135 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 213/76 (2013.01); C07D 237/20 (2013.01); C07D 239/42 (2013.01); C07D 277/52 (2013.01); C07D 285/135 (2013.01); C07D 471/04 (2013.01); C07D 487/10 (2013.01); C07D 491/20 (2013.01);
Abstract

Disclosed are compounds of Formula A-a, or a salt thereof: Where 'B' and 'R' through “R” are as defined herein, which compounds have properties for blocking Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.


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