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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9586939 B1

PDFFull Text
Date of Patent:
Mar. 07, 2017

Filed:

May. 28, 2012

Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof

Applicants:

Frank Wu, Jinan, CN;

Aichen Wang, Jinan, CN;

Inventors:

Frank Wu, Jinan, CN;

Aichen Wang, Jinan, CN;

Assignee:

XUANZHU PHARMA CO., LTD., Jinan, CN;

Attorney:

Kilpatrick Townsend & Stockton LLP

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 403/14 (2006.01); C07D 239/94 (2006.01); C07D 451/02 (2006.01); C07D 453/02 (2006.01); C07D 471/08 (2006.01); C07D 487/08 (2006.01); C07D 491/107 (2006.01); C07D 493/08 (2006.01); C07D 498/08 (2006.01); A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 491/08 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 239/94 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 451/02 (2013.01); C07D 453/02 (2013.01); C07D 471/08 (2013.01); C07D 487/08 (2013.01); C07D 491/08 (2013.01); C07D 491/107 (2013.01); C07D 493/08 (2013.01); C07D 498/08 (2013.01);
Abstract

The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R, R, R, R, R, R, R, X, L, T, Z and q are as defined in the specification. The invention also relates to a process for preparing the same, a pharmaceutical composition and a pharmaceutical formulation containing the derivative, use of the derivative for treating excessive proliferative diseases and chronic obstructive pulmonary disease and use of the derivative in the manufacture of a medicament for treating excessive proliferative diseases and chronic obstructive pulmonary disease.

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