The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 07, 2017

Filed:

Sep. 24, 2013
Applicants:

Michelle R. Machacek, Brookline, MA (US);

Eric T. Romeo, Allston, MA (US);

Solomon D. Kattar, Arlington, MA (US);

Matthew Christopher, Brookline, MA (US);

Michael D. Altman, Needham, MA (US);

Alan B. Northrup, Reading, MA (US);

John Michael Ellis, Needham, MA (US);

Brendan O'boyle, Milpitas, CA (US);

Anthony Donofrio, Cambridge, MA (US);

Jonathan Grimm, Ashburn, VA (US);

Michael H. Reutershan, Brookline, MA (US);

Kaleen Konrad Childers, Medfield, MA (US);

Ryan D. Otte, Natick, MA (US);

Brandon Cash, Framingham, MA (US);

Yves Ducharme, Brookline, MA (US);

Andrew M. Haidle, Cambridge, MA (US);

Kerrie Spencer, Woonsocket, RI (US);

Dilrukshi Vitharana, Somerville, MA (US);

Lingyun Wu, Shanghai, CN;

LI Zhang, Shanghai, CN;

Peng Zhang, Shanghai, CN;

Christian Beaulieu, Laval, CA;

Daniel Guay, Lachine, CA;

Inventors:

Michelle R. Machacek, Brookline, MA (US);

Eric T. Romeo, Allston, MA (US);

Solomon D. Kattar, Arlington, MA (US);

Matthew Christopher, Brookline, MA (US);

Michael D. Altman, Needham, MA (US);

Alan B. Northrup, Reading, MA (US);

John Michael Ellis, Needham, MA (US);

Brendan O'Boyle, Milpitas, CA (US);

Anthony Donofrio, Cambridge, MA (US);

Jonathan Grimm, Ashburn, VA (US);

Michael H. Reutershan, Brookline, MA (US);

Kaleen Konrad Childers, Medfield, MA (US);

Ryan D. Otte, Natick, MA (US);

Brandon Cash, Framingham, MA (US);

Yves Ducharme, Brookline, MA (US);

Andrew M. Haidle, Cambridge, MA (US);

Kerrie Spencer, Woonsocket, RI (US);

Dilrukshi Vitharana, Somerville, MA (US);

Lingyun Wu, Shanghai, CN;

Li Zhang, Shanghai, CN;

Peng Zhang, Shanghai, CN;

Christian Beaulieu, Laval, CA;

Daniel Guay, Lachine, CA;

Assignees:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Merck Canada Inc., Kirkland, Quebec, CA;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/10 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 498/04 (2006.01); C07D 413/14 (2006.01); C07D 239/42 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 9/0019 (2013.01); A61K 9/0073 (2013.01); A61K 9/0075 (2013.01); A61K 9/2027 (2013.01); A61K 9/4858 (2013.01); C07D 239/42 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01); A61K 9/10 (2013.01);
Abstract

Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.


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