The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Jan. 22, 2013
Applicant:
Hoffmann-la Roche Inc., Nutley, NJ (US);
Inventors:
Robert Alan Goodnow, Jr., Gillette, NJ (US);
Matthew Michael Hamilton, Hackettstown, NJ (US);
Agnieszka Kowalczyk, Mine Hill, NJ (US);
Achyutharao Sidduri, Livingston, NJ (US);
Assignee:
HOFFMANN-LA ROCHE INC., Nutley, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/452 (2006.01); C07D 239/14 (2006.01); C07D 417/12 (2006.01); C07D 277/593 (2006.01); C07C 327/32 (2006.01); A61K 47/48 (2006.01); C07C 237/52 (2006.01);
U.S. Cl.
CPC ...
C07D 277/593 (2013.01); A61K 47/48061 (2013.01); A61K 47/48092 (2013.01); A61K 47/48215 (2013.01); C07C 237/52 (2013.01); C07C 327/32 (2013.01); C07D 207/452 (2013.01); C07D 239/14 (2013.01); C07D 417/12 (2013.01);
Abstract
The invention relates to compounds of formula (I): wherein R, R, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3.