The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
May. 31, 2013
Bernhard Hubert Geierstanger, Solana Beach, CA (US);
Jan Grunewald, San Diego, CA (US);
Badry Bursulaya, Escondito, CA (US);
Bernhard Hubert Geierstanger, Solana Beach, CA (US);
Jan Grunewald, San Diego, CA (US);
Badry Bursulaya, Escondito, CA (US);
Novartis AG, Basel, CH;
Abstract
The present invention provides methods of site-specific labeling of antibodies, using proteins having 4'-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences ('peptide tags') incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates.