The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Apr. 24, 2013
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Gregory L. Verdine, Newton, MA (US);
Yoshihiko Norimine, Tsukuba, JP;
Lourdes Gude-Rodriguez, Cambridge, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/21 (2006.01); A61K 47/48 (2006.01); A61K 31/22 (2006.01); A61K 31/405 (2006.01); C07D 209/28 (2006.01); C07D 309/30 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48061 (2013.01); A61K 31/22 (2013.01); A61K 31/405 (2013.01); A61K 47/481 (2013.01); A61K 47/48092 (2013.01); A61K 47/48107 (2013.01); C07D 209/28 (2013.01); C07D 309/30 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01);
Abstract
Therapeutic conjugates containing a statin or a modified statin (collectively 'statin') linked to a therapeutic agent (also referred to as a drug herein) are targeted to the liver by the statin or modified statin and thereby deliver the therapeutic agent to liver cells.