The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Sep. 08, 2008
Applicants:
Jonathan D Powell, Baltimore, MD (US);
Charles George Drake, Baltimore, MD (US);
Paul Zarek, McLean, VA (US);
Inventors:
Jonathan D Powell, Baltimore, MD (US);
Charles George Drake, Baltimore, MD (US);
Paul Zarek, McLean, VA (US);
Assignee:
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61P 37/00 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A61K 39/39558 (2013.01);
Abstract
Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.