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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9585875 B1

PDFFull Text
Date of Patent:
Mar. 07, 2017

Filed:

Dec. 19, 2012

Trpm8 antagonists

Applicant:

Dompé S.p.a., L'Aquila, IT;

Inventors:

Alessio Moriconi, L'Aquila, IT;

Gianluca Bianchini, L'Aquila, IT;

Sandro Colagioia, L'Aquila, IT;

Laura Brandolini, L'Aquiula, IT;

Andrea Aramini, L'Aquila, IT;

Chiara Liberati, Via Olgettina, IT;

Silvia Bovolenta, Via Olgettina, IT;

Assignee:

DOMPÉ FARMACEUTICI S.P.A., Milan, IT;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Matthew Coughlin

Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/427 (2006.01); A61K 31/426 (2006.01); A61K 31/4245 (2006.01); A61K 31/421 (2006.01); C07D 277/56 (2006.01); C07D 417/04 (2006.01); C07D 417/10 (2006.01); C07D 417/12 (2006.01); C07D 263/42 (2006.01); A61K 31/472 (2006.01);
U.S. Cl.
CPC ...
A61K 31/426 (2013.01); A61K 31/421 (2013.01); A61K 31/4245 (2013.01); A61K 31/4439 (2013.01); A61K 31/472 (2013.01); C07D 263/42 (2013.01); C07D 277/56 (2013.01); C07D 417/04 (2013.01); C07D 417/10 (2013.01); C07D 417/12 (2013.01);
Abstract

The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exhacerbated respiratory disorders and urological disorders.

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