The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2017
Filed:
Aug. 31, 2012
Salim Merali, Bryn Mawr, PA (US);
Oscar Mauricio Perez Leal, Barranquilla, CO;
Magid Abou-gharbia, Exton, PA (US);
Wayne E. Childers, New Hope, PA (US);
Salim Merali, Bryn Mawr, PA (US);
Oscar Mauricio Perez Leal, Barranquilla, CO;
Magid Abou-Gharbia, Exton, PA (US);
Wayne E. Childers, New Hope, PA (US);
TEMPLE UNIVERSITY—Of The Commonwealth System of Higher Education, Philadelphia, PA (US);
Abstract
The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase ('SSAT'), wherein translation of an mRNA comprising the encoded SSAT has increased basal translation and increased stimulated translation, compared to a wild-type mRNA encoding SSAT. Methods of use for the nucleic acid are also provided. Methods and compositions are also provided for reducing ischemia-reperfusion injury in organs or tissue for transplantation.