The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2017

Filed:

Nov. 08, 2012
Applicant:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Xudong Fan, Saline, MI (US);

Yunbo Guo, Ann Arbor, MI (US);

Maung Kyaw Khaing Oo, Ann Arbor, MI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); G01N 21/31 (2006.01); G01N 21/64 (2006.01); G01N 21/65 (2006.01); G01N 21/03 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54373 (2013.01); G01N 21/31 (2013.01); G01N 21/64 (2013.01); G01N 21/65 (2013.01); G01N 21/658 (2013.01); G01N 2021/0346 (2013.01);
Abstract

3-dimensional surface-enhanced Raman scattering (SERS), as well as absorption/fluorescence/luminescence detection is carried out using a platform based on nanoparticle-functionalized flow-through multi-hole capillaries for rapid analyte detection. The configuration provides an increased active area and fluidic channels for efficient sample delivery, and also confines and transmits light for a large signal accumulation. Using a capillary consisting of thousands of micron-sized holes adsorbed with gold nanoparticles, a detection limit better than 100 fM is achieved.


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