The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2017

Filed:

Sep. 20, 2013
Applicant:

California Institute of Technology, Pasadena, CA (US);

Inventors:

Samuel Njoroge, Pasadena, CA (US);

John Gorman, Carlsbad, CA (US);

George Maltezos, Merrick, NY (US);

Axel Scherer, Pasadena, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/06 (2006.01); B01L 3/00 (2006.01); B01L 7/00 (2006.01); C12M 1/00 (2006.01); B01J 19/24 (2006.01); G01N 27/447 (2006.01);
U.S. Cl.
CPC ...
C12M 47/06 (2013.01); C12N 1/06 (2013.01); C12N 1/066 (2013.01); B01L 3/5027 (2013.01); B01L 7/52 (2013.01); B01L 2300/1883 (2013.01); C12M 21/00 (2013.01); G01N 27/44791 (2013.01);
Abstract

Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber.


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