The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2017

Filed:

Dec. 09, 2013
Applicants:

University of Washington Through Its Center for Commercialization, Seattle, WA (US);

Pacific Lutheran University, Tacoma, WA (US);

Inventors:

Andrew J. Boydston, Seattle, WA (US);

Neal A. Yakelis, Tacoma, WA (US);

Ronald Jay Berenson, Seattle, WA (US);

Derek C. Church, Seattle, WA (US);

Gregory I. Peterson, Seattle, WA (US);

Michael Larsen, Seattle, WA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C08G 71/04 (2006.01); A61K 47/48 (2006.01); C08G 81/02 (2006.01); C08G 85/00 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
C08G 71/04 (2013.01); A61K 47/48053 (2013.01); A61K 47/48192 (2013.01); A61K 47/48246 (2013.01); A61K 47/48715 (2013.01); C08G 81/028 (2013.01); C08G 85/002 (2013.01); B82Y 5/00 (2013.01);
Abstract

A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.


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