The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2017

Filed:

Nov. 06, 2012
Applicant:

Medimmune, Llc, Gaithersburg, MD (US);

Inventors:

Nazzareno Dimasi, Gaithersburg, MD (US);

Ryan Fleming, Gaithersburg, MD (US);

Binyam Bezabeh, Gaithersburg, MD (US);

Changshou Gao, Gaithersburg, MD (US);

Antonio Digiandomenico, Gaithersburg, MD (US);

Paul Warrener, Gaithersburg, MD (US);

Charles Stover, Gaithersburg, MD (US);

Bret Sellman, Gaithersburg, MD (US);

Mladen Tomich, Gaithersburg, MD (US);

Reena Varkey, Gaithersburg, MD (US);

Partha S. Chowdhury, Gaithersburg, MD (US);

Ralph Minter, Cambridge, GB;

Sandrine Guillard, Cambridge, GB;

Steven Rust, Cambridge, GB;

Vignesh Venkatraman, Cambridge, GB;

Assignee:

MedImmune, LLC, Gaithersburg, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/12 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); C07K 16/00 (2013.01); C07K 16/1214 (2013.01); C07K 16/22 (2013.01); C07K 16/468 (2013.01); C07K 2316/52 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/64 (2013.01); C07K 2317/66 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/94 (2013.01);
Abstract

The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins.


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