The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2017
Filed:
Nov. 08, 2013
Applicant:
Alphabeta Ab, Djursholm, SE;
Inventor:
Jan Johansson, Stockholm, SE;
Assignee:
AlphaBeta AB, Djursholm, SE;
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01); G01N 33/00 (2006.01); C07K 1/113 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 1/1136 (2013.01); G01N 33/6896 (2013.01); G01N 2500/04 (2013.01); G01N 2800/2821 (2013.01); G01N 2800/2828 (2013.01);
Abstract
The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the α-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders.