The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2017
Filed:
Oct. 07, 2013
Hetero Research Foundation, Hyderabad, Andrah Pradesh, IN;
Bandi Parthasaradhi Reddy, Andrah Pradesh, IN;
Kura Rathnakar Reddy, Andrah Pradesh, IN;
Dasari Muralidhara Reddy, Andrah Pradesh, IN;
Rapolu Raji Reddy, Andrah Pradesh, IN;
Kesireddy Subash Chander Reddy, Andrah Pradesh, IN;
Bandi Vamsi Krishna, Andrah Pradesh, IN;
HETERO RESEARCH FOUNDATION, , IN;
Abstract
The present invention provides novel solvated forms of darunavir and processes for their preparation. The present invention also provides novel processes for the preparation of darunavir amorphous form and pharmaceutical compositions comprising it. Thus, for example, darunavir 2-methyl-2-butanol solvate was dissolved in methylene dichloride, distilled under vacuum at 45° C. to obtain a residue, cyclohexane was added to the residue and stirred for 30 hours at 20 to 25° C., and the separated solid was filtered, washed with cyclohexane and dried under vacuum at 50° C. for 12 hours to yield darunavir amorphous form.