The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2017

Filed:

Apr. 05, 2013
Applicants:

Anthony E. Boitano, San Diego, CA (US);

Michael Cooke, San Diego, CA (US);

Shifeng Pan, San Diego, CA (US);

Peter G. Schultz, La Jolla, CA (US);

John Tellew, La Jolla, CA (US);

Yongqin Wan, Irvine, CA (US);

Xing Wang, San Diego, CA (US);

Inventors:

Anthony E. Boitano, San Diego, CA (US);

Michael Cooke, San Diego, CA (US);

Shifeng Pan, San Diego, CA (US);

Peter G. Schultz, La Jolla, CA (US);

John Tellew, La Jolla, CA (US);

Yongqin Wan, Irvine, CA (US);

Xing Wang, San Diego, CA (US);

Assignees:

Novartis AG, Basel, CH;

The Scripps Research Institute, La Jolla, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 473/34 (2006.01); A61K 38/00 (2006.01); C07D 487/04 (2006.01); C12N 5/0789 (2010.01); C07D 473/16 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 473/34 (2013.01); A61K 38/00 (2013.01); C07D 473/16 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C12N 5/0647 (2013.01); C12N 2501/38 (2013.01); C12N 2501/60 (2013.01);
Abstract

The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.


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