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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9580409 B1

PDFFull Text
Date of Patent:
Feb. 28, 2017

Filed:

Nov. 07, 2012

Modulators of opioid receptors and methods of use thereof

Applicant:

Sunovion Pharmaceuticals Inc., Marlborough, MA (US);

Inventors:

Scott Malcolm, Southborough, MA (US);

Carrie Bowen, Uxbridge, MA (US);

Laurence Melnick, Watertown, MA (US);

Linghong Xie, Southborough, MA (US);

Assignee:

SUNOVION PHARMACEUTICALS, INC., Marlborough, MA (US);

Attorney:

Heslin Rothenberg Farley & Mesiti P.C.

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 403/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 487/04 (2006.01); C07D 487/14 (2006.01); C07D 498/04 (2006.01); C07D 471/04 (2006.01); C07D 405/14 (2006.01); C07D 487/10 (2006.01); C07D 491/10 (2006.01); A61K 31/4178 (2006.01); A61K 31/4184 (2006.01); A61K 31/4196 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/501 (2006.01); A61K 31/551 (2006.01); A61K 31/553 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61K 31/4178 (2013.01); A61K 31/4184 (2013.01); A61K 31/4196 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/501 (2013.01); A61K 31/551 (2013.01); A61K 31/553 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 487/14 (2013.01); C07D 491/10 (2013.01); C07D 498/04 (2013.01);
Abstract

Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

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