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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9580398 B1

PDFFull Text
Expired
Date of Patent:
Feb. 28, 2017

Filed:

Apr. 02, 2013

Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders

Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Brent R. Stockwell, New York, NY (US);

Scott J. Dixon, New York, NY (US);

Rachid Skouta, New York, NY (US);

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);

Attorney:

Bryan Cave LLP

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
C07D 213/80 (2006.01); C07C 211/50 (2006.01); A61K 31/44 (2006.01); A61K 31/245 (2006.01); C07D 309/14 (2006.01); C07C 255/58 (2006.01); C07C 271/16 (2006.01); C07C 271/24 (2006.01); C07C 271/28 (2006.01); C07C 205/57 (2006.01); C07C 205/58 (2006.01); C07D 401/12 (2006.01); C07D 239/26 (2006.01); C07C 229/60 (2006.01); C07C 233/54 (2006.01); C07C 237/30 (2006.01); C07D 295/088 (2006.01); C07D 211/58 (2006.01); C07D 295/30 (2006.01); C07D 213/36 (2006.01); A61K 31/325 (2006.01); A61K 31/351 (2006.01); A61K 31/4465 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); A61K 45/06 (2006.01); C07C 69/78 (2006.01); C07D 295/192 (2006.01);
U.S. Cl.
CPC ...
C07D 309/14 (2013.01); A61K 31/245 (2013.01); A61K 31/325 (2013.01); A61K 31/351 (2013.01); A61K 31/4465 (2013.01); A61K 31/495 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); C07C 69/78 (2013.01); C07C 205/57 (2013.01); C07C 205/58 (2013.01); C07C 211/50 (2013.01); C07C 229/60 (2013.01); C07C 233/54 (2013.01); C07C 237/30 (2013.01); C07C 255/58 (2013.01); C07C 271/16 (2013.01); C07C 271/24 (2013.01); C07C 271/28 (2013.01); C07D 211/58 (2013.01); C07D 213/36 (2013.01); C07D 213/80 (2013.01); C07D 239/26 (2013.01); C07D 295/088 (2013.01); C07D 295/192 (2013.01); C07D 295/30 (2013.01); C07D 401/12 (2013.01); C07C 2101/02 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01); C07C 2101/18 (2013.01); C07C 2101/20 (2013.01); C07C 2103/74 (2013.01);
Abstract

The present invention provides, inter alia, a compound having the structure: (Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.

Find Patent Forward Citations

Stockwell, Brent. (2017). Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders (U.S. Patent No. 9580398). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9580398

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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