IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9580390 B1

PDFFull Text
Date of Patent:
Feb. 28, 2017

Filed:

Oct. 12, 2012

Indazole compounds as kinase inhibitors and method of treating cancer with same

Applicant:

University Health Network, Toronto, CA;

Inventors:

Heinz W. Pauls, Oakville, CA;

Radoslaw Laufer, Oakville, CA;

Yong Liu, Oakville, CA;

Sze-Wan Li, Toronto, CA;

Bryan T. Forrest, Burlington, CA;

Yunhui Lang, Markham, CA;

Narendra Kumar B. Patel, Brampton, CA;

Louise G. Edwards, Mississauga, CA;

Grace Ng, Richmond Hill, CA;

Peter Brent Sampson, Oakville, CA;

Miklos Feher, New York, NY (US);

Donald E. Awrey, Simcoe, CA;

Assignee:

University Health Network, Toronto, CA;

Attorneys:

McCarter & English, LLP

Steven G. Davis

Wei Song

Primary Examiner:

Kamal Saeed

Int. Cl.
CPC ...
C07D 231/56 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 405/14 (2006.01); C07D 451/06 (2006.01); C07D 491/107 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 403/10 (2006.01); C07D 413/04 (2006.01); C07D 413/10 (2006.01); C07D 493/10 (2006.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 451/06 (2013.01); C07D 491/107 (2013.01); C07D 493/10 (2013.01);
Abstract

The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.

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