The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2017
Filed:
Jun. 12, 2014
Applicant:
Canadian Blood Services, Ottawa, CA;
Inventor:
Ed Pryzdial, Vancouver, CA;
Assignee:
Canadian Blood Services, Ottawa, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/36 (2006.01); A61K 38/48 (2006.01); C07D 207/452 (2006.01); C12N 9/74 (2006.01); C12N 9/48 (2006.01); A61K 38/49 (2006.01); C12N 9/64 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4846 (2013.01); A61K 38/49 (2013.01); C07D 207/452 (2013.01); C12N 9/6432 (2013.01); C12Y 304/21006 (2013.01);
Abstract
The present disclosure provides a C-terminal tethered amino acid for modulating the thrombolytic, fibrinolytic and/or anticoagulant properties of a coagulation protein. The present disclosure also provides a coagulation protein having a catalytic site modified, either at the histidine or serine residue, with the C-terminal tethered amino acid as well as therapeutic applications of those modified coagulation proteins.