The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2017
Filed:
Sep. 01, 2015
Applicant:
Oncomed Pharmaceuticals, Inc., Redwood City, CA (US);
Inventors:
Sanjeev H. Satyal, San Carlos, CA (US);
Satyajit Sujit Kumar Mitra, South Pasadena, CA (US);
Austin L. Gurney, San Francisco, CA (US);
Assignee:
ONCOMED PHARMACEUTICALS, INC., Redwood City, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 6/00 (2006.01); A61K 31/00 (2006.01); A61K 31/28 (2006.01); A61K 31/282 (2006.01); A61K 31/33 (2006.01); A61K 31/335 (2006.01); A61K 31/337 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 38/17 (2006.01); C07K 14/705 (2006.01); G01N 33/50 (2006.01); A61K 31/4745 (2006.01); A61K 31/7068 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/177 (2013.01); A61K 31/282 (2013.01); A61K 31/337 (2013.01); A61K 31/4745 (2013.01); A61K 31/7068 (2013.01); A61K 39/39591 (2013.01); C07K 14/705 (2013.01); G01N 33/5011 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/70 (2013.01);
Abstract
The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such Wnt antagonists. In particular, the invention discloses soluble FZD, SFRP and Ror receptors and their use.