The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2017
Filed:
Jun. 01, 2015
Applicant:
Jiarui Biopharmaceuticals, Ltd., Yixing, CN;
Inventor:
Shaosong Chu, Encinitas, CA (US);
Assignee:
Jiarui Biopharmaceuticals, Ltd., Yixing, CN;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/00 (2006.01); A61K 38/14 (2006.01); C07K 9/00 (2006.01); A61K 38/06 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 31/4745 (2006.01); A61K 31/407 (2006.01); A61K 31/704 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4745 (2013.01); A61K 31/407 (2013.01); A61K 31/704 (2013.01); A61K 47/481 (2013.01); A61K 47/48338 (2013.01);
Abstract
Peptide-drug conjugates comprising p-aminobenzyl carbamoyl or p-aminobenzolyl carbonate self-immolating linkers are disclosed. The peptide-drug conjugates comprise a peptide moiety that can be cleaved by cellular proteases, bound to the self-immolating linker, which linker is bound to a cytotoxic drug moiety. Upon cleavage of the peptide moiety, the linker self-immolates, releasing the cytotoxic drug in active form. Dimeric structures of the peptide drug conjugates comprising two molecules of cytotoxic drug per conjugate are also disclosed.