The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Jul. 14, 2011
Applicant:
Troy E. Wilson, San Marino, CA (US);
Inventor:
Troy E. Wilson, San Marino, CA (US);
Assignee:
Ambrx, Inc., La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08F 8/02 (2006.01); C08F 8/30 (2006.01); C08G 65/329 (2006.01); C08G 65/333 (2006.01); C08G 65/325 (2006.01); C08F 216/16 (2006.01);
U.S. Cl.
CPC ...
C08G 65/325 (2013.01); C08F 8/02 (2013.01); C08F 8/30 (2013.01); C08F 216/16 (2013.01); C08G 65/329 (2013.01); C08G 65/333 (2013.01);
Abstract
The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.