The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Apr. 26, 2013
Mdc Max-delbruck-centrum Fur Molekulare Medizin Berlin-buch, Berlin, DE;
Fresenius Medical Care Deutschland Gmbh, Bad Homburg, DE;
Rudolf Kunze, Berlin, DE;
Gerd Wallukat, Berlin, DE;
Peter Rosenthal, Ludenscheid, DE;
Richard Straube, Ludenscheid, DE;
MDC Max-Delbruck-Centrum Fur Molekulare Medizin Berlin-Buch, Berlin-Buch, DE;
Fresenius Medical Care Deutschland GmbH, Bad Homburg, DE;
Abstract
A peptide having an EDof less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the EDvalue is measured by bioassay.