The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Dec. 19, 2013
Medimmune, Llc, Gaithersburg, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Solomon Langermann, Baltimore, MD (US);
Linda Liu, Clarksville, MD (US);
Sheng Yao, Columbia, MD (US);
Lieping Chen, Hamden, CT (US);
Michael Glen Overstreet, Crownsville, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Anti-human B7-H4 antibody '6H3', antigen-binding fragments, derivatives, and humanized variants thereof that are capable of immunospecifically binding to B7-H4, and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases are disclosed. In preferred embodiments, the molecules are used to retard or prevent tumor growth, inhibit tumor-mediated suppression, eliminate tumors and/or deplete or block the activity of tumor-associated macrophages ('TAMs') so as to alter their activity and/or decrease TAM-mediated immune suppression.