The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Mar. 28, 2013
Applicant:
University of Exeter, Exeter, GB;
Inventors:
Assignee:
University of Exeter, Exeter, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/08 (2006.01); C07K 14/33 (2006.01); C07K 16/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/33 (2013.01); A61K 39/08 (2013.01); C07K 16/1282 (2013.01); A61K 39/00 (2013.01);
Abstract
There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused byand/or caused by (or associated with the presence of) active epsilon toxin.