The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Nov. 02, 2010
Sunghoon Kim, Seoul, KR;
Jung Min Han, Seoul, KR;
Hyeong Rae Kim, Daejeon, KR;
Dong Ju Jeon, Daejeon, KR;
Jong Hwan Song, Chungcheongbuk-do, KR;
Kyung Eun Park, Daejeon, KR;
Sunghoon Kim, Seoul, KR;
Jung Min Han, Seoul, KR;
Hyeong Rae Kim, Daejeon, KR;
Dong Ju Jeon, Daejeon, KR;
Jong Hwan Song, Chungcheongbuk-do, KR;
Kyung Eun Park, Daejeon, KR;
SNU R&DB FOUNDATION, Seoul, KR;
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, Daejeon, KR;
Abstract
The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.