The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 21, 2017

Filed:

Mar. 18, 2016
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Robert Blake, South San Francisco, CA (US);

Paola Di Lello, South San Francisco, CA (US);

Jason Drummond, South San Francisco, CA (US);

Christine Johanna Heideker, South San Francisco, CA (US);

Lorna Kategaya, South San Francisco, CA (US);

Till Maurer, South San Francisco, CA (US);

Jeremy M. Murray, South San Francisco, CA (US);

Chudi Ndubaku, South San Francisco, CA (US);

Richard Pastor, South San Francisco, CA (US);

Lionel Rouge, South San Francisco, CA (US);

Vickie Tsui, Burlingame, CA (US);

Ingrid E. Wertz, South San Francisco, CA (US);

Kebing Yu, South San Francisco, CA (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/02 (2006.01); C07D 213/73 (2006.01); A61K 31/44 (2006.01); A61K 45/06 (2006.01); C07D 409/04 (2006.01); A61K 31/4436 (2006.01); A61K 31/5355 (2006.01); C07D 401/04 (2006.01); A61K 31/444 (2006.01); A61K 31/506 (2006.01); A61K 31/496 (2006.01); A61K 31/4439 (2006.01); C07D 213/74 (2006.01); C07D 403/04 (2006.01);
U.S. Cl.
CPC ...
C07D 213/73 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/5355 (2013.01); A61K 45/06 (2013.01); C07D 213/74 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 409/04 (2013.01);
Abstract

2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for modulating USP7, and for treating cancer and immune disorders such as inflammation mediated by USP7. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.


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