The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Jun. 11, 2012
Applicants:
Jianrong LI, Dublin, OH (US);
Yu Zhang, Columbus, OH (US);
Rongzhang Wang, Columbus, OH (US);
Inventors:
Assignee:
Ohio State Innovation Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); C12N 7/04 (2006.01); A61K 39/155 (2006.01); A61K 39/12 (2006.01); A61K 38/45 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/155 (2013.01); A61K 38/45 (2013.01); A61K 39/12 (2013.01); C12N 7/00 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/542 (2013.01); A61K 2039/543 (2013.01); C12N 2760/18334 (2013.01); C12N 2760/18362 (2013.01); C12N 2760/18534 (2013.01); C12N 2760/18562 (2013.01); C12N 2760/18634 (2013.01); C12N 2760/18662 (2013.01); C12Y 207/07006 (2013.01);
Abstract
The present invention includes methyltransferase (MTase)-defective recombinant viruses as live vaccine candidates for human metapneumovirus (hMPV), human respiratory syncytial virus (hRSV), and human parainfluenza virus type 3 (PIV3). Here the inventors provide the technical description for generating MTase-defective paramyxoviruses useful as immunogens, as well as related materials and methods.