The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Nov. 06, 2012
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Warren M. Zapol, Cambridge, MA (US);
Binglan Yu, Lexington, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 33/00 (2006.01); A61K 35/18 (2015.01); A61M 1/02 (2006.01);
U.S. Cl.
CPC ...
A61K 33/00 (2013.01); A61K 35/18 (2013.01); A61M 1/0281 (2013.01); A61M 2202/0275 (2013.01); A61M 2202/0429 (2013.01);
Abstract
Compositions and methods for treating red blood cells are disclosed. The methods include contacting a red blood cell sample ex vivo with an amount of nitric oxide or a nitric oxide-releasing compound sufficient to convert at least a portion of the extracellular ferrous hemoglobin present in the red blood cell sample to ferric hemoglobin. Red blood cells administered to a mammal following the ex vivo treatment have reduced adverse effects on the mammal to which they are administered.