The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
Jun. 07, 2013
Invicro, Llc, Boston, MA (US);
Kelly Davis Orcutt, Somerville, MA (US);
John Hoppin, Boston, MA (US);
Jacob Hesterman, Boston, MA (US);
Christian Lackas, Cologne, DE;
Kelly Davis Orcutt, Somerville, MA (US);
John Hoppin, Boston, MA (US);
Jacob Hesterman, Boston, MA (US);
Christian Lackas, Cologne, DE;
Other;
Abstract
A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.