The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2017
Filed:
Dec. 17, 2014
Manufacture of active highly phosphorylated human n-acetylgalactosamine-6-sulfatase and uses thereof
Applicant:
Biomarin Pharmaceutical Inc., Novato, CA (US);
Inventors:
Vish Koppaka, San Rafael, CA (US);
Michel Claude Vellard, San Rafael, CA (US);
Augustus O. Okhamafe, Concord, CA (US);
Kidisti Araya, Berkeley, CA (US);
Assignee:
BioMarin Pharmaceutical Inc., Novato, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); A61K 9/08 (2006.01); A61K 38/46 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); A61K 9/08 (2013.01); A61K 38/465 (2013.01); A61K 38/00 (2013.01); C12Y 301/06004 (2013.01);
Abstract
This invention provides compositions of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase (GALNS), and pharmaceutical compositions and formulations thereof, methods of producing and purifying GALNS, and its use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the GALNS enzyme, e.g., Mucopolysaccharidosis IVa (MPS IVa or Morquio A syndrome).