The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2017
Filed:
Oct. 23, 2014
Abbvie Deutschland Gmbh & Co. KG, Wiesbaden, DE;
Abbvie Inc., North Chicago, IL (US);
Andreas Kling, Mannheim, DE;
Helmut Mack, Ludwigshafen, DE;
Katja Jantos, Mannheim, DE;
Achim Moeller, Grunstadt, DE;
Wilfried Hornberger, Neustadt, DE;
Charles W. Hutchins, Green Oaks, IL (US);
AbbVie Deutschland GmbH & Co. KG, Wiesbaden, DE;
AbbVie Inc., North Chicago, IL (US);
Abstract
The present invention relates to novel carboxamide compounds and their use as a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity and to a method for the therapeutic and/or prophylactic treatment by administering an effective amount of at least one of these carboxamide compounds. The carboxamide compounds are compounds of the general formula I in whichW—Ris selected from and R, R, R, R, Y, Y, Y, Y, X, Q, m, k, Rand Rhave the meanings mentioned in the claims, the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y, Y, Yand Yare CR, or one or two of the variables Yto Yare a nitrogen atom and the remaining variables are CR, wherein the radicals Rmay be identical or different and have the meanings mentioned in the claims.