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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9566366 B1

PDFFull Text
Date of Patent:
Feb. 14, 2017

Filed:

Aug. 10, 2016

Multiple-layer immune barrier for donor cells

Applicant:

Beta-o2 Technologies Ltd., Patech-Tikva, IL;

Inventors:

Uriel Barkai, MP Hof-Carmel, IL;

Avi Rotem, Petach Tikva, IL;

Yehezkel Bremer, Ra'anana, IL;

Tova Neufeld, Ariel, IL;

Assignee:

Beta-O2 Technologies Ltd., Petach-Tikva, IL;

Attorney:

Greenberg Traurig, LLP

Primary Examiner:

Bethany Barham

Assistant Examiner:

Dominic Lazaro

Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61J 3/06 (2006.01); A61P 1/18 (2006.01); A61K 35/12 (2015.01); A61K 35/39 (2015.01); A61L 27/00 (2006.01); A61L 27/34 (2006.01); A61L 27/36 (2006.01); A61L 27/56 (2006.01); A61L 27/50 (2006.01); C12N 5/00 (2006.01); A01N 1/02 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61L 27/00 (2013.01); A01N 1/0231 (2013.01); A61L 27/34 (2013.01); A61L 27/36 (2013.01); A61L 27/505 (2013.01); A61L 27/56 (2013.01); C12N 5/0012 (2013.01); C12N 5/0676 (2013.01); A61L 2400/18 (2013.01); A61L 2420/02 (2013.01); A61L 2420/08 (2013.01); A61L 2430/40 (2013.01);
Abstract

A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.

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