The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2017
Filed:
Oct. 30, 2014
Applicants:
Markus Grompe, Portland, OR (US);
Willscott Naugler, Portland, OR (US);
Inventors:
Markus Grompe, Portland, OR (US);
Willscott Naugler, Portland, OR (US);
Assignee:
OREGON HEALTH & SCIENCE UNIVERSITY, Portland, OR (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/00 (2006.01); A61K 38/18 (2006.01); C12Q 1/68 (2006.01); G01N 30/72 (2006.01); A01K 67/027 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1825 (2013.01); A01K 67/0276 (2013.01); A01K 67/0278 (2013.01); C12Q 1/6883 (2013.01); G01N 30/7233 (2013.01); A01K 2217/052 (2013.01); A01K 2217/054 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); A01K 2267/0393 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Methods of normalizing bile acid production in a mouse engrafted with human hepatocytes by the administration of human FGF19 are disclosed. Also disclosed is a transgenic host animal, such as a mouse, that expresses human FGF19 that has normalized bile acid production when engrafted with human hepatocytes.