The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2017
Filed:
Oct. 19, 2015
Applicant:
Roche Innovation Center Copenhagen A/s, Hoersholm, DK;
Inventors:
Gregroy Hardee, Del Mar, CA (US);
Ellen Marie Straarup, Birkerod, DK;
Marie Wickstrom Lindholm, Malmo, SE;
Henrik Orum, Vaerlose, DK;
Henrik Frydenlund Hansen, Rodovre, DK;
Assignee:
Roche Innovation Center Copenhagen A/S, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 31/712 (2006.01); C12N 15/113 (2010.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/712 (2013.01); A61K 9/0053 (2013.01); C12N 15/113 (2013.01); C12N 15/1136 (2013.01); C12N 2310/11 (2013.01); C12N 2310/113 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3341 (2013.01); C12N 2320/30 (2013.01);
Abstract
The invention provides for LNA oligomers, for the treatment of a metabolic or liver disorder, wherein the LNA oligomer is administered orally in a unit dose of less than 50 mgs/kg, wherein the LNA oligomer is administered in the presence of a penetration (permeation) enhancer.