The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2017
Filed:
Feb. 25, 2014
Hyun Koo, Philadelphia, PA (US);
Danielle Benoit, Rochester, NY (US);
Marlise I. Klein, Rochester, NY (US);
Megan L. Falsetta Wood, Rochester, NY (US);
Hyun Koo, Philadelphia, PA (US);
Danielle Benoit, Rochester, NY (US);
Marlise I. Klein, Rochester, NY (US);
Megan L. Falsetta Wood, Rochester, NY (US);
University of Rochester, Rochester, NY (US);
Abstract
The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed.