The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2017
Filed:
Oct. 31, 2013
Applicants:
Kyoto University, Kyoto, JP;
The Regents of the University of California, Oakland, CA (US);
Inventors:
Noboru Ashida, Kyoto, JP;
Masayuki Yokode, Kyoto, JP;
Michael Karin, La Jolla, CA (US);
Dat Nguyen Tien, Kyoto, JP;
Assignees:
KYOTO UNIVERSITY, Kyoto, JP;
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); A61K 49/00 (2006.01); G01N 33/50 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0276 (2013.01); A01K 67/027 (2013.01); A61K 49/0008 (2013.01); C12N 9/12 (2013.01); C12N 15/09 (2013.01); G01N 33/5008 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/035 (2013.01); A01K 2267/0387 (2013.01); C12Y 207/1101 (2013.01);
Abstract
The present invention provides a non-human animal IKKβ which shows fibrosis of tissue, since it lacks IKKβ gene in a myofibroblast- and/or smooth muscle cell-specific manner. Since the non-human animal shows pathology highly similar to scleroderma, it is extremely useful as an animal model of scleroderma.