The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2017
Filed:
Dec. 20, 2013
Applicant:
The Penn State Research Foundation, University Park, PA (US);
Inventors:
Kenneth C Keiler, Boalsburg, PA (US);
Stephen J Benkovic, State College, PA (US);
Assignee:
The Penn State Research Foundation, University Park, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/67 (2006.01); C12Q 1/66 (2006.01); C12N 15/10 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/66 (2013.01); C12N 15/1086 (2013.01); C12N 15/67 (2013.01); C12Q 1/6897 (2013.01);
Abstract
Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, includingand other pathogens of military and civilian interest. Identified cyclic or linear peptides are further selected by in vivo selection methods, kill bacterial pathogens when added exogenously, and/or eliminate plasmids carrying antibiotic resistance or virulence genes. The molecular target of each cyclic peptide is in the tmRNA pathway and the tmRNA pathway is inhibited in vitro and in vivo by the addition of the peptides.