The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2017
Filed:
Feb. 26, 2014
Applicant:
Halozyme, Inc., San Diego, CA (US);
Inventors:
Louis Bookbinder, San Diego, CA (US);
Anirban Kundu, San Diego, CA (US);
Gregory I. Frost, Palm Beach, FL (US);
Assignee:
Halozyme, Inc., San Diego, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/47 (2006.01); A61K 9/00 (2006.01); A61K 47/48 (2006.01); C12N 9/26 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2474 (2013.01); A61K 9/0048 (2013.01); A61K 38/47 (2013.01); A61K 47/48215 (2013.01); C12Y 302/01035 (2013.01);
Abstract
Provided are methods for reducing intraocular pressure in the eye of a subject by administering neutral active soluble active hyaluronidase glycoproteins (sHASEGPs) and modified forms thereof to the eye. The sHASEGPs are soluble forms of human PH20 hyaluronidase. Also provided are the sHASEGPs, methods of manufacture, and uses thereof. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described. The sHASEGPs include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain.