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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9562071 B1

PDFFull Text
Expired
Date of Patent:
Feb. 07, 2017

Filed:

Jun. 16, 2014

Method for preparing eptifibatide

Applicant:

Hybio Pharmaceutical Co., Ltd., Shenzhen, Guangdong, CN;

Inventors:

Xu Kang, Shenzhen, CN;

Jian Liu, Shenzhen, CN;

Yaping Ma, Shenzhen, CN;

Jiancheng Yuan, Shenzhen, CN;

Assignee:

HYBIO PHARMACEUTICAL CO., LTD., Shenzhen, CN;

Attorney:

Parker Highlander PLLC

Primary Examiner:

Hasan Ahmed

Assistant Examiner:

Kaipeen Yang

Int. Cl.
CPC ...
A61K 38/04 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01);
Abstract

Provided is a method for preparing eptifibatide, wherein the method comprises: obtaining an eptifibatide refined peptide solution; and obtaining and freeze-drying an eptifibatide refined peptide concentrate after rotary evaporation of the eptifibatide refined peptide solution, wherein the concentration of the eptifibatide refined peptide concentrate is 15-30 mg/ml and the temperature of rotary evaporation is 251° C.-35° C. The preparation method of the eptifibatide refined peptide solution is as follows: coupling Cys with a resin to obtain a Cys-resin; obtaining a polypeptide having a sequence as represented by SEQ ID NO: 1 by gradually coupling the Cys-resin with Pro, Trp, Asp, Gly, Har and Mpa; and obtaining the eptifibatide refined peptide solution through oxidation, cleavage, purification and transfer to salt.

Find Patent Forward Citations

Kang, Xu. (2017). Method for preparing eptifibatide (U.S. Patent No. 9562071). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9562071

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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