IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9562019 B1

PDFFull Text
Date of Patent:
Feb. 07, 2017

Filed:

Dec. 21, 2007

Substituted pyridazines as egfr and/or kras inhibitors

Applicants:

Hakim Djaballah, Scarsdale, NY (US);

Harold E. Varmus, New York, NY (US);

David Shum, Forest Hills, NY (US);

Romel Somwar, New York, NY (US);

Alexander Chucholowski, San Diego, CA (US);

Mohan Santhanam Thiruvazhi, San Diego, CA (US);

Inventors:

Hakim Djaballah, Scarsdale, NY (US);

Harold E. Varmus, New York, NY (US);

David Shum, Forest Hills, NY (US);

Romel Somwar, New York, NY (US);

Alexander Chucholowski, San Diego, CA (US);

Mohan Santhanam Thiruvazhi, San Diego, CA (US);

Assignee:

Sloan-Kettering Institute for Cancer Research, New York, NY (US);

Attorneys:

Choate, Hall, and Stewart LLP

Brenda Herschbach Jarrell

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
C07D 237/10 (2006.01); C07D 237/04 (2006.01); C07D 307/68 (2006.01); C07D 307/71 (2006.01); C07D 307/85 (2006.01); C07D 307/92 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); C07D 495/04 (2006.01); C07D 401/14 (2006.01); C07D 405/10 (2006.01); C07D 413/04 (2006.01); C07D 417/10 (2006.01);
U.S. Cl.
CPC ...
C07D 237/04 (2013.01); C07D 307/68 (2013.01); C07D 307/71 (2013.01); C07D 307/85 (2013.01); C07D 307/92 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 405/10 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 417/10 (2013.01); C07D 471/04 (2013.01); C07D 495/04 (2013.01);
Abstract

The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.

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