The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 07, 2017

Filed:

Dec. 18, 2015
Applicants:

Novartis Ag, Basel, CH;

Array Biopharma, Inc., Boulder, CO (US);

Inventors:

Christoph Max Krell, Basel, CH;

Marian Misun, Basel, CH;

Daniel Andreas Niederer, Basel, CH;

Werner Heinz Pachinger, Basel, CH;

Marie-Christine Wolf, Basel, CH;

Daniel Zimmermann, Basel, CH;

Weidong Liu, Boulder, CO (US);

Peter J. Stengel, Boulder, CO (US);

Paul Nichols, Boulder, CO (US);

Assignees:

Array BioPharma, Inc., Boulder, CO (US);

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 235/06 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61K 47/38 (2006.01); A61K 9/20 (2006.01); C30B 7/08 (2006.01); C30B 29/54 (2006.01); C07D 235/08 (2006.01);
U.S. Cl.
CPC ...
C07D 235/06 (2013.01); A61K 9/2018 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/38 (2013.01); C07D 235/08 (2013.01); C30B 7/08 (2013.01); C30B 29/54 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.


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